Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …

Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

The elongation of eukaryotic selenoproteins relies on a poorly understood process of
interpreting in-frame UGA stop codons as selenocysteine (Sec). We used cryo-electron …

Translation, the process of mRNA-encoded protein synthesis, requires a complex apparatus,
composed of the ribosome, tRNAs and additional protein factors, including aminoacyl tRNA …

In all domains of life, selenocysteine (Sec) is delivered to the ribosome by selenocysteine-
specific tRNA (tRNASec) with the help of a specialized translation factor, SelB in bacteria …

BACKGROUND: The amino acid selenocysteine (Sec) is the major biological form of the
trace element selenium. Sec is co-translationally incorporated in selenoproteins. There are …

Translational GTPases (trGTPases) play key roles in facilitating protein synthesis on the
ribosome. Despite the high degree of evolutionary conservation in the sequences of their …

Abstract Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally
similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change …

Elongation factors Tu (EF-Tu) and SelB are translational GTPases that deliver aminoacyl-
tRNAs (aa-tRNAs) to the ribosome. In each canonical round of translation elongation, aa …