Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …

Nutrient transition metals are required cofactors for many proteins to perform functions
necessary for life. As such, the concentration of nutrient metals is carefully maintained to …

Severe outbreaks and deaths have been linked to the emergence and global spread of
fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time …

Leveraging systems biology approaches, we illustrate how metabolically distinct species of
Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating …

Bacterial therapy has become a key strategy against intestinal infectious diseases in recent
years. Moreover, regulating the gut microbiota through traditional fecal microbiota …

Background Until recently, metronidazole was the first-line treatment for Clostridioides
difficile infection and it is still commonly used. Though resistance has been reported due to …

The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut
microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well …

Clostridia comprise bacteria of environmental, biotechnological and medical interest and
many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen …

Iron is an essential element for almost all living organisms, but can be extremely toxic in high
concentrations. All organisms must therefore employ homeostatic mechanisms to finely …