Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Chronic pain remains an enormous health problem affecting approximatively 30% of the
world's population. Opioids as the first line analgesics often leads to undesirable side effects …

Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone
metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species …

Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a
common progressive neurodegenerative disease that usually presents with clinical features …

Pain during photodynamic therapy (PDT) is the main limiting adverse effect in its use in
dermatology. Given its multifactorial nature, we reviewed both intrinsic and extrinsic factors …

In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including
spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …

Central neuropathic pain (CNP) in the spinal cord, such as chronic pain after spinal cord
injury (SCI), is an incurable ailment. However, little is known about the spinal cord …

Chronic pain affects millions of people and often causes major health problems.
Accumulating evidence indicates that the production of reactive oxygen species (ROS), such …

Long-term potentiation of glutamatergic transmission has been observed after physiological
learning or pathological injuries in different brain regions, including the spinal cord …

The gate control theory proposes that Aβ mechanoreceptor inputs to spinal pain
transmission T neurons are gated via feedforward inhibition, but it remains unclear how …