Melanoma is an aggressive malignancy originating from pigment-producing melanocytes.
The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies …

Cutaneous melanoma is an aggressive tumor responsible for 90% of mortality related to skin
cancer. In the recent years, the discovery of driving mutations in melanoma has led to better …

Dedifferentiated melanoma (DM) and undifferentiated melanoma (UM) is defined as a
primary or metastatic melanoma showing transition between conventional and …

Diagnosis of spindle cell/sarcomatoid melanoma may be challenging due to frequent loss of
expression of melanocytic marker (s) and histomorphologic resemblance to various …

The distinction between undifferentiated melanoma (UM) or dedifferentiated melanoma
(DM) from undifferentiated or unclassifiable sarcoma can be difficult and requires the careful …

Phenotypic plasticity of malignant melanoma is a well-known phenomenon. Several
translational studies and small case series have reported this clinical and biological entity …

Among mesenchymal tumors, MAML2 gene rearrangements have been described in a
subset of composite hemangioendothelioma and myxoinflammatory fibroblastic sarcoma …

Metastatic melanoma (MM) has a poor prognosis and is attributed to late diagnoses only
when metastases has already occurred. Thus, early diagnosis is crucial to improve its …

Undifferentiated carcinoma metastatic to the bowel is uncommon in surgical pathology
practice and might be confused with primary gastrointestinal carcinoma, melanoma …

This review provides a conceptual approach to dedifferentiation across a variety of tumor
types, with particular attention to genetic events that tie together morphologically disparate …