During the last decades, remarkable progress has been made in further understanding the
complex molecular regulatory networks that maintain hematopoietic stem cell (HSC) …

The correct maintenance and differentiation of hematopoietic stem cells (HSC) in bone
marrow is vital for the maintenance and operation of the human blood system. GATA2 plays …

Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related
clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature …

Oxygen (O2) plays a key role in cellular homeostasis. O2 levels are tightly regulated in vivo
such that each tissue receives an optimal amount to maintain physiologic status. Physiologic …

Renal fibrosis is a common outcome of various renal injuries, leading to structural
destruction and functional decline of the kidney, and is also a critical prognostic indicator …

The complex and dynamic interaction between cellular energy control and gene expression
modulation is shown by the intersection between mitochondrial metabolism and epigenetics …

One of the key regulators of hematopoietic stem cell (HSC) maintenance is cellular
metabolism. Resting HSCs use anaerobic glycolysis as the main source of energy. During …

In this issue of Blood, Aljou fi et al 1 report that physiologic oxygen tension or “physioxia”
downmodulates ten-eleven translocation 2 (Tet2) activity in hematopoietic stem cells (HSCs) …

Objective: To investigate the radiation response and proteomic profiling of esophageal
epithelial cells cultured under physioxia and normoxia. Methods: The human immortalized …