A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration

U Schmidt-Erfurth, SM Waldstein - Progress in Retinal and eye Research, 2016 - Elsevier
Neovascular age-related macular degeneration (AMD) has undergone substantial break-
throughs in diagnostic as well as therapeutic respect, with optical coherence tomography …

Predictors of visual acuity after treatment of neovascular age-related macular degeneration–current perspectives

LT Phan, GK Broadhead, TH Hong… - Clinical …, 2021 - Taylor & Francis
Visual acuity is a key outcome measure in the treatment of neovascular age-related macular
degeneration (nAMD) using anti-vascular endothelial growth factor agents. Large variations …

Biomarkers as predictive factors of anti-VEGF response

M Bobadilla, A Pariente, AI Oca, R Peláez… - Biomedicines, 2022 - mdpi.com
Age-related macular degeneration is the main cause of irreversible vision in developed
countries, and intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are …

Genetic associations of anti‐vascular endothelial growth factor therapy response in age‐related macular degeneration: a systematic review and meta‐analysis

Z Wang, M Zou, A Chen, Z Liu, CA Young… - Acta …, 2022 - Wiley Online Library
Purpose To investigate the association of all reported common polymorphisms in anti‐
vascular endothelial growth factor (VEGF) therapy response and to identify potential …

Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in …

E Cobos, S Recalde, J Anter… - Acta …, 2018 - Wiley Online Library
Purpose We sought to determine if specific genetic single nucleotide polymorphisms (SNPs)
influence vascular endothelial growth factor inhibition response to ranibizumab in …

Association of the polymorphism Y402H in the CFH gene with response to anti‐VEGF treatment in age‐related macular degeneration: a systematic review and meta …

N Hong, Y Shen, CY Yu, SQ Wang… - Acta …, 2016 - Wiley Online Library
To explore whether the complement factor H (CFH) polymorphism rs1061170/Y402H is
associated with responsiveness to antivascular endothelial growth factor (VEGF) agents in …

Aflibercept administration in neovascular age-related macular degeneration refractory to previous anti-vascular endothelial growth factor drugs: a critical review and …

S Lazzeri, G Ripandelli, MS Sartini, M Parravano… - Angiogenesis, 2015 - Springer
Purpose The recent introduction of anti-VEGF drugs has widely changed the prognosis of
exudative age-related macular degeneration (AMD), even if a variable percentage of …

Association between VEGF-A and VEGFR-2 polymorphisms and response to treatment of neovascular AMD with anti-VEGF agents: a meta-analysis

M Wu, H Xiong, Y Xu, X Xiong, H Zou… - British Journal of …, 2017 - bjo.bmj.com
Aims The purpose of this study is to investigate whether gene polymorphisms of the vascular
endothelial growth factor A (VEGF-A) and its receptor (VEGFR-2) have a pharmacogenetics …

A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration

K Yamashiro, K Mori, S Honda, M Kano, Y Yanagi… - Scientific reports, 2017 - nature.com
We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF
treatment for exudative age-related macular degeneration (AMD) in a prospective cohort …

Genetic predictive biomarkers of anti-VEGF treatment response in patients with neovascular age-related macular degeneration

S Fauser, GN Lambrou - Survey of ophthalmology, 2015 - Elsevier
Anti-vascular endothelial growth factor (anti-VEGF) therapies for neovascular age-related
macular degeneration (nAMD) have proven efficacy at a study-population level, although …