During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …

While there is considerable contemporary interest in elucidating the role of placenta-derived
extracellular vesicles in normal and complicated pregnancies and their utility as biomarkers …

For many years, double-layer phospholipid membrane vesicles, released by most cells,
were not considered to be of biological significance. This stance has dramatically changed …

Background Human placenta releases specific nanovesicles (ie exosomes) into the
maternal circulation during pregnancy, however, the presence of placenta-derived …

Placental trophoblasts form the interface between the fetal and maternal environments and
serve to limit the maternal–fetal spread of viruses. Here we show that cultured primary …

Studies completed to date provide persuasive evidence that placental cell-derived
exosomes play a significant role in intercellular communication pathways that potentially …

Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

Exosomes are nanoparticles (∼ 100 nm diameter) released from cells, which can transfer
small RNAs and mRNA via the extracellular environment to cells at distant sites. We …