Regio-and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis

W Hüttel, M Müller - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2005 to 2020 Phenol coupling is a key reaction in the biosynthesis of important
biopolymers such as lignin and melanin and of a plethora of biarylic secondary metabolites …

Enzymatic dimerization in the biosynthetic pathway of microbial natural products

J Liu, A Liu, Y Hu - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to August 2020 The dramatic increase in the identification of dimeric natural
products generated by microorganisms and plants has played a significant role in drug …

Biosynthesis of Tasikamides via Pathway Coupling and Diazonium-Mediated Hydrazone Formation

GL Ma, H Candra, LM Pang, J Xiong… - Journal of the …, 2022 - ACS Publications
Naturally occurring hydrazones are rare despite the ubiquitous usage of synthetic
hydrazones in the preparation of organic compounds and functional materials. In this study …

Structure revision of the lomaiviticins

LJ Kim, M Xue, X Li, Z Xu, E Paulson… - Journal of the …, 2021 - ACS Publications
The lomaiviticins are dimeric genotoxic metabolites that contain unusual
diazocyclopentadiene functional groups and 2–4 deoxyglycoside residues. Because only 6 …

Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis

SS Elsayed, HU van der Heul, X Xiao… - Communications …, 2023 - nature.com
Angucyclines are type II polyketide natural products, often characterized by unusual
structural rearrangements through B-or C-ring cleavage of their tetracyclic backbone. While …

Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation

C Yang, L Zhang, W Zhang, C Huang, Y Zhu… - Nature …, 2022 - nature.com
Xanthone-containing natural products display diverse pharmacological properties. The
biosynthetic mechanisms of the xanthone formation have not been well documented. Here …

Flavin-enabled reductive and oxidative epoxide ring opening reactions

BC De, W Zhang, C Yang, A Mándi, C Huang… - Nature …, 2022 - nature.com
Epoxide ring opening reactions are common and important in both biological processes and
synthetic applications and can be catalyzed in a non-redox manner by epoxide hydrolases …

Genetic characterization of neosartorin biosynthesis provides insight into heterodimeric natural product generation

Y Matsuda, CH Gotfredsen, TO Larsen - Organic letters, 2018 - ACS Publications
A biosynthetic gene cluster of the fungal xanthone heterodimer neosartorin (1) was
discovered in Aspergillus novofumigatus, and its biosynthesis was investigated by a series …

Marine actinomycetes-derived angucyclines and angucyclinones with biosynthesis and activity--past 10 years (2014-2023)

X Xu, X Huang, W Xu - European Journal of Medicinal Chemistry, 2024 - Elsevier
Actinomycete bacteria derived from marine environments are a good source of natural
products with diverse biological activities such as cytotoxicity, antiviral, and antimicrobial …

Natural epoxyquinoids: isolation, biological activity and synthesis. An update

VA Shcherbinin, ER Nasibullina… - Organic & …, 2023 - pubs.rsc.org
Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse
biological activities, including, but not limited to, antibacterial, antifungal, anticancer, enzyme …