The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update
MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …
Treatment of type 2 diabetes: challenges, hopes, and anticipated successes
MA Nauck, J Wefers, JJ Meier - The lancet Diabetes & endocrinology, 2021 - thelancet.com
Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
The incretin hormone GLP‐1 and mechanisms underlying its secretion: 肠促胰岛素激素GLP‐1 及其潜在的分泌机制
L Tian, T Jin - Journal of diabetes, 2016 - Wiley Online Library
摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是一种细胞类型特异性的胰高血糖
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …
Lipid metabolism and lipid signals in aging and longevity
Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …
of genetic pathways have been discovered to regulate lifespan in model organisms …
Ghrelin, CCK, GLP-1, and PYY (3–36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB
The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …
management of obesity and type 2 diabetes mellitus and novel developments in …
Commensal bacteria make GPCR ligands that mimic human signalling molecules
LJ Cohen, D Esterhazy, SH Kim, C Lemetre… - Nature, 2017 - nature.com
Commensal bacteria are believed to have important roles in human health. The
mechanisms by which they affect mammalian physiology remain poorly understood, but …
mechanisms by which they affect mammalian physiology remain poorly understood, but …
Endocannabinoids—at the crossroads between the gut microbiota and host metabolism
Various metabolic disorders are associated with changes in inflammatory tone. Among the
latest advances in the metabolism field, the discovery that gut microorganisms have a major …
latest advances in the metabolism field, the discovery that gut microorganisms have a major …
Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
K Tsuboi, T Uyama, Y Okamoto, N Ueda - Inflammation and Regeneration, 2018 - Springer
The plant Cannabis sativa contains cannabinoids represented by Δ 9-tetrahydrocannabinol,
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …
Gut microbiota, enteroendocrine functions and metabolism
Highlights•The gut microbiota interacts with enteroendocrine cells.•SCFAs triggers gut
peptide secretion through GPR43-dependent and GPR41-dependent mechanisms.•The gut …
peptide secretion through GPR43-dependent and GPR41-dependent mechanisms.•The gut …
Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
The incretin hormones gastric inhibitory polypeptide and especially glucagon-like peptide
(GLP) have an important physiological function in augmenting postprandial insulin …
(GLP) have an important physiological function in augmenting postprandial insulin …