Does CCL19 act as a double-edged sword in cancer development?

A Gowhari Shabgah, ZMJ Al-Obaidi… - Clinical and …, 2022 - academic.oup.com
Cancer is considered a life-threatening disease, and several factors are involved in its
development. Chemokines are small proteins that physiologically exert pivotal roles in …

Co-option of endogenous viral sequences for host cell function

JA Frank, C Feschotte - Current opinion in virology, 2017 - Elsevier
Highlights•Endogenous viral elements (EVEs) account for a substantial fraction (∼ 10%) of
mammalian genomes.•EVEs represent an abundant source of coding and noncoding …

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

M Segel, B Lash, J Song, A Ladha, CC Liu, X Jin… - Science, 2021 - science.org
Eukaryotic genomes contain domesticated genes from integrating viruses and mobile
genetic elements. Among these are homologs of the capsid protein (known as Gag) of long …

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

R Hamamoto, Y Furukawa, M Morita, Y Iimura… - Nature cell …, 2004 - nature.com
Colorectal and hepatocellular carcinomas are some of the leading causes of cancer deaths
worldwide, but the mechanisms that underly these malignancies are not fully understood …

Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality

R Ono, K Nakamura, K Inoue, M Naruse, T Usami… - Nature …, 2006 - nature.com
By comparing mammalian genomes, we and others have identified actively transcribed
Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and …

Turning junk into gold: domestication of transposable elements and the creation of new genes in eukaryotes

JN Volff - Bioessays, 2006 - Wiley Online Library
Autonomous transposable elements, generally considered as junk and selfish, encode
transposition proteins that can bind, copy, break, join or degrade nucleic acids as well as …

Clinical and molecular features of treatment‐related neuroendocrine prostate cancer

S Akamatsu, T Inoue, O Ogawa… - International Journal of …, 2018 - Wiley Online Library
Abstract Treatment‐related neuroendocrine prostate cancer is a lethal form of prostate
cancer that emerges in the later stages of castration‐resistant prostate cancer treatment …

[PDF][PDF] Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas

JH Luo, B Ren, S Keryanov, GC Tseng, UNM Rao… - …, 2006 - Wiley Online Library
This study analyzed gene expression patterns and global genomic alterations in
hepatocellular carcinomas (HCC), hepatoblastomas (HPBL), tissue adjacent to HCC and …

A study of the influence of sex on genome wide methylation

J Liu, M Morgan, K Hutchison, VD Calhoun - PloS one, 2010 - journals.plos.org
Sex differences in methylation status have been observed in specific gene-disease studies
and healthy methylation variation studies, but little work has been done to study the impact …

G9a, a multipotent regulator of gene expression

SR Shankar, AG Bahirvani, VK Rao, N Bharathy… - Epigenetics, 2013 - Taylor & Francis
Lysine methylation of histone and non-histone substrates by the methyltransferase G9a is
mostly associated with transcriptional repression. Recent studies, however, have highlighted …