Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

S Zeng, X Liu, YS Kafuti, H Kim, J Wang… - Chemical Society …, 2023 - pubs.rsc.org
Since their inception, rhodamine dyes have been extensively applied in biotechnology as
fluorescent markers or for the detection of biomolecules owing to their good optical physical …

Lactate‐Oxidase‐Instructed Cancer Diagnosis and Therapy

S Jiang, X Chen, J Lin, P Huang - Advanced Materials, 2023 - Wiley Online Library
Lactate oxidase (LOx) has attracted extensive interest in cancer diagnosis and therapy in
recent years owing to its specific catalysis on l‐lactate; its catalytic process consumes …

Tumor-generated reactive oxygen species storm for high-performance ferroptosis therapy

L Huang, J Zhu, W Xiong, J Feng, J Yang, X Lu, Y Lu… - ACS …, 2023 - ACS Publications
Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration of
Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the …

Engineering lactate-modulating nanomedicines for cancer therapy

J Chen, Y Zhu, C Wu, J Shi - Chemical Society Reviews, 2023 - pubs.rsc.org
Lactate in tumors has long been considered “metabolic junk” derived from the glycolysis of
cancer cells and utilized only as a biomarker of malignancy, but is presently believed to be a …

A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity

Y Zhang, X Du, Z He, S Gao, L Ye, J Ji, X Yang… - ACS nano, 2023 - ACS Publications
Ferroptosis activation has been considered a mighty weapon for cancer treatment, and
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …

[HTML][HTML] Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

H Gao, Z Cao, H Liu, L Chen, Y Bai, Q Wu, X Yu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to
activate the Fenton reaction or Fenton-like reaction to generate strong oxidative hydroxyl …

Insights into the effect of catalytic intratumoral lactate depletion on metabolic reprogramming and immune activation for antitumoral activity

J Zhao, Z Tian, S Zhao, D Feng, Z Guo… - Advanced …, 2023 - Wiley Online Library
Lactate, a characteristic metabolite of the tumor microenvironment (TME), drives
immunosuppression and promotes tumor progression. Material‐engineered strategies for …

Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis

Y Hu, Y Xu, RL Mintz, X Luo, Y Fang, YH Lao, HF Chan… - Biomaterials, 2023 - Elsevier
Tumor-positive resection margins after surgery can result in tumor recurrence and
metastasis. Although adjuvant postoperative radiotherapy and chemotherapy have been …

A targeted nanomodulator capable of manipulating tumor microenvironment against metastasis

H Tian, L Zhou, Y Wang, EC Nice, C Huang… - Journal of Controlled …, 2022 - Elsevier
Recently, lactate has been considered as an alternative direct energy substance to glucose
for tumor proliferation and metastasis. Meanwhile, mitochondria, as important energy …

Nanomaterials: small particles show huge possibilities for cancer immunotherapy

Z Chen, Z Yue, K Yang, S Li - Journal of Nanobiotechnology, 2022 - Springer
With the economy's globalization and the population's aging, cancer has become the
leading cause of death in most countries. While imposing a considerable burden on society …