Proteins are not monolithic entities; rather, they can contain multiple domains that mediate
distinct interactions, and their functionality can be regulated through post-translational …

Using expression profiles from postmortem prefrontal cortex samples of 624 dementia
patients and non‐demented controls, we investigated global disruptions in the co‐regulation …

Among the signaling molecules indirectly linked to many different cell surface receptors,
RAS proteins essentially respond to a diverse range of extracellular cues. They control …

We utilized induced pluripotent stem cells (iPSCs) derived from Huntington's disease (HD)
patients as a human model of HD and determined that the disease phenotypes only …

Huntington disease (HD) is an inherited neurodegenerative disease caused by a CAG
expansion in the HTT gene. Using yeast two-hybrid methods, we identified a large set of …

Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by
an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new …

Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and
can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived …

Huntington's disease (HD) represents an important model for neurodegenerative disorders
and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) …

Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat
expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the …

Huntington's disease is a fatal autosomal-dominant neurodegenerative disorder,
characterized by neuronal cell dysfunction and loss, primarily in the striatum, cortex and …