Fluorescent polymer nanoparticles based on dyes: seeking brighter tools for bioimaging

A Reisch, AS Klymchenko - Small, 2016 - Wiley Online Library
Speed, resolution and sensitivity of today's fluorescence bioimaging can be drastically
improved by fluorescent nanoparticles (NPs) that are many‐fold brighter than organic dyes …

Polymeric micelle stability

SC Owen, DPY Chan, MS Shoichet - Nano today, 2012 - Elsevier
Polymeric micelles provide a platform that can be carefully tuned for drug delivery. The nano-
scale aggregates form spontaneously in aqueous solution and can be used to overcome …

Self‐assembled peptide amphiphile micelles containing a cytotoxic T‐cell epitope promote a protective immune response in vivo

M Black, A Trent, Y Kostenko, JS Lee, C Olive… - Advanced …, 2012 - infona.pl
A model cytotoxic T‐cell epitope is linked to a synthetic lipid tail, forming a peptide
amphiphile that self‐assembles into cylindrical micelles. The micelles are capable of …

Molecular engineering solutions for therapeutic peptide delivery

H Acar, JM Ting, S Srivastava, JL LaBelle… - Chemical Society …, 2017 - pubs.rsc.org
Proteins and their interactions in and out of cells must be well-orchestrated for the healthy
functioning and regulation of the body. Even the slightest disharmony can cause diseases …

In vivo tumor-targeted dual-modal fluorescence/CT imaging using a nanoprobe co-loaded with an aggregation-induced emission dye and gold nanoparticles

J Zhang, C Li, X Zhang, S Huo, S Jin, FF An, X Wang… - Biomaterials, 2015 - Elsevier
As an intensely studied computed tomography (CT) contrast agent, gold nanoparticle has
been suggested to be combined with fluorescence imaging modality to offset the low …

Structural properties of soluble peptide amphiphile micelles

A Trent, R Marullo, B Lin, M Black, M Tirrell - Soft Matter, 2011 - pubs.rsc.org
Peptide amphiphiles (PAs) self-assemble into dynamic micellar structures that provide a
multivalent display of functional peptides and are currently being developed for use in a …

Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo

T Wei, J Liu, H Ma, Q Cheng, Y Huang, J Zhao… - Nano …, 2013 - ACS Publications
Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy,
especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we …

[HTML][HTML] Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma

EJ Chung, Y Cheng, R Morshed, K Nord, Y Han… - Biomaterials, 2014 - Elsevier
Glioblastoma-targeted drug delivery systems facilitate efficient delivery of chemotherapeutic
agents to malignant gliomas, while minimizing systemic toxicity and side effects. Taking …

The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles

Y Huang, K Jiang, X Zhang… - … & Translational Medicine, 2020 - Wiley Online Library
Chronic kidney disease (CKD) affects 15% of the US adult population. However, most
clinically available drugs for CKD show low bioavailability to the kidneys and non‐specific …

PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)2000 Induces Morphological …

G Bor, JH Lin, KY Lin, HC Chen… - … Applied Materials & …, 2022 - ACS Publications
Considering the broad therapeutic potential of omega-3 polyunsaturated fatty acids such as
docosahexaenoic acid (DHA), here we study the effect of PEGylation of DHA-incorporated …