Major mechanisms for the recognition of pathogens by immune cells have evolved to
employ classical and non-classical major histocompatibility complex class I (MHC I) …

The recent approval of letermovir marks a new era of therapy for human cytomegalovirus
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed,
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …

The signal peptidase complex (SPC) is an essential membrane complex in the endoplasmic
reticulum (ER), where it removes signal peptides (SPs) from a large variety of secretory pre …

Lassa virus (LASV) is a human pathogen, causing substantial morbidity and mortality,.
Similar to other Arenaviridae, it presents a class-I spike complex on its surface that facilitates …

Human cytomegalovirus is a widespread pathogen of major medical importance. It causes
significant morbidity and mortality in immunocompromised individuals, and congenital …

CD8+ T cells not only are critical mediators of adaptive immunity but also may exhibit innate-
like properties such as surface expression of NKG2C, an activating receptor typically …

During the first trimester of pregnancy the uterus is massively infiltrated by decidual natural
killer cells (dNK). These cells are not killers, but they rather provide a microenvironment that …

The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly
from clinical pathology samples were investigated, focusing on variation, multiple-strain …