Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart
failure. Detailed deciphering gene expression perturbations and cell–cell interactions of …

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Successful establishment of pregnancy requires adhesion of an embryo to the endometrium
and subsequent invasion into the maternal tissue. Abnormalities in this critical process of …

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are
an integral part of tissue physiology and immunity. Determining how immune cells inhabit …

Decidual natural killer (dNK) cells are the tissue-resident and major subpopulation of NK
cells at the maternal-fetal interface. It has been demonstrated that dNK cells play pivotal …

Research on the placenta as the interface between the mother and the fetus has been
undertaken for some 150 years, and in 2 subsequent reviews, we attempted to summarize …

In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …