Three-dimensional spheroid culture of human mesenchymal stem cells: offering therapeutic advantages and in vitro glimpses of the in vivo state

BL Yen, CC Hsieh, PJ Hsu, CC Chang… - Stem cells …, 2023 - academic.oup.com
As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …

Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids

Y Ohori-Morita, A Ashry, K Niibe… - Stem Cells Translational …, 2024 - academic.oup.com
Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative
medicine owing to their self-renewal properties, multilineage differentiation …

Dental pulp stem cells-derived cannabidiol-treated organoid-like microspheroids show robust osteogenic potential via upregulation of WNT6

F Liu, Q Wu, Q Liu, B Chen, X Liu, JL Pathak… - Communications …, 2024 - nature.com
Dental pulp stem cells (DPSC) have shown osteogenic and bone regenerative potential.
Improving the in situ bone regeneration potential of DPSC is crucial for their application as …

Unilateral biportal endoscopic versus microscopic transforaminal lumbar interbody fusion for degenerative lumbar spinal stenosis in China: study protocol for a …

Z Wu, T Luo, Y Yang, M Pang, R Chen, P Xie, B Yang… - BMJ open, 2024 - bmjopen.bmj.com
Introduction Degenerative lumbar spinal stenosis is a common cause of low back or leg pain
and disability in the elderly population. Patients with spinal stenosis who fail to respond to …

[HTML][HTML] Osteogenic differentiation of mesenchymal stem cell spheroids: A microfluidic device and electrochemiluminescence imaging study

K Hiramoto, A Konno, Y Nashimoto, A Hirano-Iwata… - Electrochimica …, 2024 - Elsevier
Human mesenchymal stem cells (MSCs) have attracted attention as a major cellular source
for regenerative medicine and preclinical studies. Three-dimensional (3D) cell culture …

Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis Research

C Yun, SH Kim, KM Kim, MH Yang, MR Byun… - International Journal of …, 2024 - mdpi.com
Bone differentiation is crucial for skeletal development and maintenance. Its dysfunction can
cause various pathological conditions such as rickets, osteoporosis, osteogenesis …

Tissue-Specific Mesenchymal Stem Cells as an Emerging Modality in Cell-Based Therapy for Regenerative Medicine

Y Sharma, S Mahapatra, S Mohanty - STEM CELL BIOLOGY: A …, 2025 - World Scientific
Mesenchymal stem cells (MSCs) are adult sourced stem cells which are currently the
popular choice of therapeutics in regenerative medicine. They can be extracted from various …

Dental pulp stem cells-derived cannabidiol-pretreated micro-spheroids showed robust osteogenic potential via upregulation of WNT6

F Liu, Q Wu, Q Liu, B Chen, X Liu, JL Pathak… - 2023 - researchsquare.com
Dental pulp stem cells (DPSC)-derived 3D-aggregates/spheroids have shown robust
soft/hard tissue regeneration potential. However, difficulties to control the cell number, size …

Modulating the Angiogenic and Immunomodulatory Capacities of Stem Cell-Derived Extracellular Vesicles in Culture Through Mechanical Microenvironment …

WY Kang, S Jung, H Jeong, HM Woo, H Bae… - Available at SSRN … - papers.ssrn.com
Stem cell-derived extracellular vesicles (EVs) have attracted attention as a promising
therapy which could address the limitations of current stem cell treatments. Nevertheless, the …