The role of JAK/STAT signaling pathway and its inhibitors in diseases

P Xin, X Xu, C Deng, S Liu, Y Wang, X Zhou… - International …, 2020 - Elsevier
The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

miRNAs insights into rheumatoid arthritis: Favorable and detrimental aspects of key performers

AS Doghish, A Ismail, HA El-Mahdy, SY Elkhawaga… - Life Sciences, 2023 - Elsevier
Rheumatoid arthritis (RA) is a severe autoimmune inflammation that mostly affects the joints.
It's a multifactorial disease. Its clinical picture depends on genetic and epigenetic factors …

MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact

G Evangelatos, GE Fragoulis, V Koulouri… - Autoimmunity reviews, 2019 - Elsevier
Over the last decade, many epigenetic mechanisms that contribute in the pathogenesis of
autoimmune disorders have been revealed. MicroRNAs (miRNAs) are small, non-coding …

MicroRNA-mediated epigenetic regulation of rheumatoid arthritis susceptibility and pathogenesis

C Chang, L Xu, R Zhang, Y Jin, P Jiang, K Wei… - Frontiers in …, 2022 - frontiersin.org
MicroRNAs (miRNAs) play crucial roles in regulating the transcriptome and development of
rheumatoid arthritis (RA). Currently, a comprehensive map illustrating how miRNAs regulate …

Comprehensive overview of microRNA function in rheumatoid arthritis

X Peng, Q Wang, W Li, G Ge, J Peng, Y Xu, H Yang… - Bone Research, 2023 - nature.com
MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have
emerged as vital epigenetic regulators of both pathological and physiological processes in …

[HTML][HTML] The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis

J Yang, Z Li, L Wang, X Yun, Y Zeng, JPL Ng… - Pharmacological …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which is associated
with the dysregulation of autoimmune response. In recent years, early diagnosis, aggressive …

Toward overcoming treatment failure in rheumatoid arthritis

Z Wang, J Huang, D Xie, D He, A Lu… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and
bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines …

Preliminary exploration of hsa_circ_0032131 levels in peripheral blood as a potential diagnostic biomarker of osteoarthritis

Y Wang, C Wu, Y Yang, Z Ren, MJ Lammi… - Genetic Testing and …, 2019 - liebertpub.com
Background: Osteoarthritis (OA) is a common chronic degenerative joint disease
characterized by articular cartilage degeneration and synovitis. CircRNAs are increasingly …

Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking and in …

P Xin, X Xu, H Zhang, Y Hu, C Deng, S Sun… - Pharmaceutical …, 2023 - Taylor & Francis
Abstract Context Duhuo Jisheng pill (DHJS) is a classic traditional Chinese medicine (TCM)
formula for rheumatoid arthritis (RA). The effective components and therapeutic mechanisms …

Biomarkers (mRNAs and non-coding RNAs) for the diagnosis and prognosis of rheumatoid arthritis

Y Jiang, S Zhong, S He, J Weng, L Liu, Y Ye… - Frontiers in …, 2023 - frontiersin.org
In recent years, diagnostic and therapeutic approaches for rheumatoid arthritis (RA) have
continued to improve. However, in the advanced stages of the disease, patients are unable …