Severe periodontitis, a destructive inflammatory disease of the supporting tissues of the
teeth, ranks sixth in terms of global spread, affecting about 11% of the population …

Objectives Efforts towards achieving durable resin–dentin bonds have been made for
decades, including the understanding of the mechanisms underlying hybrid layer (HL) …

Adhesive systems are resin-based materials that reach their final mechanical properties
through a polymerization process. Previous literature correlated the failure of the adhesive …

Objective Success in adhesive dentistry means long lasting restorations. However, there is
substantial evidence that this ideal objective is not always achieved. Current research in this …

This review provides a detailed description of matrix metalloproteinases (MMPs), focusing
on those that are known to have critical roles in bone and periodontal disease. Periodontal …

Dentin can be described as a biological composite with collagen matrix embedded with
nanosized hydroxyapatite mineral crystallites. Matrix metalloproteinases (MMPs) and …

Objective Endogenous dentin collagenolytic enzymes, matrix metalloproteinases (MMPs)
and cysteine cathepsins, are responsible for the time-dependent hydrolysis of collagen …

The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-
colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized …

OBJECTIVES: Contemporary adhesives lose their bond strength to dentin regardless of the
bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid …

Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …