For over a century, the neuron doctrine—which states that the neuron is the structural and
functional unit of the nervous system—has provided a conceptual foundation for …

Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the
spatial location being looked at. The representation is allocentric, in that the responses are …

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus
challenge the long-standing hypothesis that hippocampal long-term potentiation-like …

The mechanisms for pattern completion and pattern separation are described in the context
of a theory of hippocampal function in which the hippocampal CA3 system operates as a …

Theories of associative memory suggest that successful memory storage and recall depend
on a balance between two complementary processes: pattern separation (to minimize …

The aims of the paper are to update Rolls' quantitative computational theory of hippocampal
function and the predictions it makes about the different subregions (dentate gyrus, CA3 and …

Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory
function by decorrelating overlapping input patterns (pattern separation). A second …

Theoretical neuroscience provides a quantitative basis for describing what nervous systems
do, determining how they function, and uncovering the general principles by which they …

The ability to find one's way depends on neural algorithms that integrate information about
place, distance and direction, but the implementation of these operations in cortical …

More than three decades of research have demonstrated a role for hippocampal place cells
in representation of the spatial environment in the brain. New studies have shown that place …