Pathological roles of the homeostatic chemokine CXCL12
R Janssens, S Struyf, P Proost - Cytokine & growth factor reviews, 2018 - Elsevier
CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …
The chemokine system in cancer biology and therapy
A Mantovani, B Savino, M Locati, L Zammataro… - Cytokine & growth factor …, 2010 - Elsevier
Chemokines are a key component of cancer-related inflammation. Chemokines and
chemokine receptors are downstream of genetic events that cause neoplastic transformation …
chemokine receptors are downstream of genetic events that cause neoplastic transformation …
CXCR7 impact on CXCL12 biology and disease
L Sánchez-Martín, P Sánchez-Mateos… - Trends in molecular …, 2013 - cell.com
It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both
chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and …
chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and …
Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism
CC Lord, G Thomas, JM Brown - … et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Dysregulation of lipid metabolism underlies many chronic diseases such as obesity,
diabetes, cardiovascular disease, and cancer. Therefore, understanding enzymatic …
diabetes, cardiovascular disease, and cancer. Therefore, understanding enzymatic …
The biochemistry and biology of the atypical chemokine receptors
A subset of chemokine receptors, initially called “silent” on the basis of their apparent failure
to activate conventional signalling events, has recently attracted growing interest due to their …
to activate conventional signalling events, has recently attracted growing interest due to their …
The role and mechanism of epithelial-to-mesenchymal transition in prostate cancer progression
In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes
the beginning of the end disease, which eventually leads to cancer death. Many …
the beginning of the end disease, which eventually leads to cancer death. Many …
Chemokines and cytokines: Axis and allies in prostate cancer pathogenesis
Chemokines are recognized as the major contributor to various tumorigenesis, tumor
heterogeneity, and failures of current cancer therapies. The tumor microenvironment (TME) …
heterogeneity, and failures of current cancer therapies. The tumor microenvironment (TME) …
Colorectal cancer: the contribution of CXCL12 and its receptors CXCR4 and CXCR7
AA Goïta, D Guenot - Cancers, 2022 - mdpi.com
Simple Summary Many signaling pathways are involved in cancer progression, and among
these pathways, the CXCL12 axis and its two receptors CXCR4 and CXCR7 are well …
these pathways, the CXCL12 axis and its two receptors CXCR4 and CXCR7 are well …
CXCR7 targeting and its major disease relevance
Chemokine receptors are the target of small peptide chemokines. They play various
important roles in physiological and pathological processes. CXCR7, later renamed ACKR3 …
important roles in physiological and pathological processes. CXCR7, later renamed ACKR3 …
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
N Salazar, D Muñoz, G Kallifatidis, RK Singh, M Jordà… - Molecular cancer, 2014 - Springer
Background Recent advances have revealed a significant contribution of chemokines and
their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis …
their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis …