FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that
mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in …

MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response
proteins. Increasing evidence suggests that its expression in cancer cells is critical to …

MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is
essential for repair of DNA double-strand-breaks in normal cells, has recently garnered …

Matrine (MAT) is an alkaloid in the dried roots of Sophora flavescens. The antitumor activity
has been testified in colon cancer. Howbeit, the latent mechanism is still indistinct. The …

Breast cancer is the most common and significant cancers in females regarding the loss of
life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA …

The key signature of cancer genomes is the accumulation of DNA mutations, the most
abundant of which is the cytosine-to-thymine (C-to-T) transition that results from cytosine …

Extensive epidemiological studies have demonstrated that there are associations between
variants in intron 2 of FGFR2 and the breast cancer risk in various populations; however, the …

Abstract Receptor Tyrosine Kinases (RTK) are an important family involved in numerous
signaling pathways essential for proliferation, cell survival, transcription or cell-cycle …