Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure
(BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic
stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2
mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood …

Fanconi's anemia is a rare disorder that arises from defective repair of damaged DNA. Of the
13 Fanconi's anemia genes, 3 are breast-cancer–susceptibility genes. One is identical to …

Myelodysplastic syndrome (MDS) typically presents in older adults with the acquisition of
age-related somatic mutations, whereas MDS presenting in children and younger adults is …

The Fanconi anemia (FA) pathway plays a central role in the repair of DNA interstrand
crosslinks (ICL s) and regulates cellular responses to replication stress. Homologous …

We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also
known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded …