A double take on bivalent promoters
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …
Is H3K4me3 instructive for transcription activation?
Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …
modification at the transcription start site of active genes in eukaryotes from yeast to man …
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
C Zhong, WJ Jiang, Y Yao, Z Li, Y Li, S Wang… - Nature …, 2024 - nature.com
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for
many types of cancer. Here we systematically identify genetic drivers underlying …
many types of cancer. Here we systematically identify genetic drivers underlying …
Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation
Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors
Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) has
become the dominant technique for mapping transcription factor (TF) binding regions …
become the dominant technique for mapping transcription factor (TF) binding regions …
[HTML][HTML] The language of histone crosstalk
JS Lee, E Smith, A Shilatifard - Cell, 2010 - cell.com
It has been suggested that a specific pattern of histone posttranslational modifications and
their crosstalk may constitute a code that determines transcriptional outcomes. However …
their crosstalk may constitute a code that determines transcriptional outcomes. However …
Histone acetyltransferases: challenges in targeting bi-substrate enzymes
H Wapenaar, FJ Dekker - Clinical epigenetics, 2016 - Springer
Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
The asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) acts as a repressive
mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also …
mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also …
Sharing the SAGA
D Helmlinger, L Tora - Trends in biochemical sciences, 2017 - cell.com
Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-
activators establish transcriptionally competent promoter architectures and chromatin …
activators establish transcriptionally competent promoter architectures and chromatin …
Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination
The sequence-specific transcription factor NF-Y binds the CCAAT box, one of the sequence
elements most frequently found in eukaryotic promoters. NF-Y is composed of the NF-YA …
elements most frequently found in eukaryotic promoters. NF-Y is composed of the NF-YA …