Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

E Petermann, L Lan, L Zou - Nature reviews Molecular cell biology, 2022 - nature.com
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions

L Statello, CJ Guo, LL Chen, M Huarte - Nature reviews Molecular cell …, 2021 - nature.com
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Walking a tightrope: the complex balancing act of R-loops in genome stability

JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Regulatory R-loops as facilitators of gene expression and genome stability

C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

R-loops as cellular regulators and genomic threats

MP Crossley, M Bocek, KA Cimprich - Molecular cell, 2019 - cell.com
During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?

F Fabbiano, J Corsi, E Gurrieri… - Journal of …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …

TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch

T Yadav, JM Zhang, J Ouyang, W Leung, A Simoneau… - Molecular cell, 2022 - cell.com
Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …

Heterochromatin: guardian of the genome

A Janssen, SU Colmenares… - Annual review of cell and …, 2018 - annualreviews.org
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

MA Jafri, SA Ansari, MH Alqahtani, JW Shay - Genome medicine, 2016 - Springer
Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …