Tissue mechanobiology is an emerging field with the overarching goal of understanding the
interplay between biophysical and biochemical responses affecting development …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

The extracellular matrix (ECM) provides structural support for cells and mediates cell-stromal
communications. In addition to ECM proteins, mechanical force exerted from the ECM …

Tissue stem-progenitor cell frequency has been implicated in tumor risk and progression,
but tissue-specific factors linking these associations remain ill-defined. We observed that stiff …

Many solid tumors exhibit significant genetic, cellular, and biophysical heterogeneity which
dynamically evolves during disease progression and after treatment. This constant flux in …

The influence of biomechanics on cell function has become increasingly defined over recent
years. Biomechanical changes are known to affect oncogenesis; however, these effects are …

Described herein is a protocol for producing a synthetic extracellular matrix that can be
modified in situ during three-dimensional cell culture. The hydrogel platform is established …

Breast cancer is most common in women, and in most cases there is no evidence of spread
and the primary tumor is removed, resulting in a 'cure'. However, in 10% to 30% of these …

Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …

Simple Summary Phenotypic diversity in tumors makes treatment difficult and leads to poor
prognosis. A better understanding of what causes intratumoral heterogeneity and …