Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

Nanoparticles in ocular applications and their potential toxicity

C Yang, J Yang, A Lu, J Gong, Y Yang, X Lin… - Frontiers in molecular …, 2022 - frontiersin.org
Nanotechnology has been developed rapidly in recent decades and widely applied in
ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current …

Therapeutic effect of rapamycin-loaded small extracellular vesicles derived from mesenchymal stem cells on experimental autoimmune uveitis

H Li, Z Zhang, Y Li, L Su, Y Duan, H Zhang… - Frontiers in …, 2022 - frontiersin.org
Autoimmune uveitis is a major cause of vision loss and glucocorticoids are major traditional
medications, which may induce serious complications. Rapamycin has been demonstrated …

Recent advances of ocular drug delivery systems: prominence of ocular implants for chronic eye diseases

M Mostafa, A Al Fatease, RG Alany, H Abdelkader - Pharmaceutics, 2023 - mdpi.com
Chronic ocular diseases can seriously impact the eyes and could potentially result in
blindness or serious vision loss. According to the most recent data from the WHO, there are …

Therapeutic approaches for age-related macular degeneration

RM Galindo-Camacho, C Blanco-Llamero… - International journal of …, 2022 - mdpi.com
Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying
macula is known to increase the risk of age-related macular degeneration (AMD). AMD is …

mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism

X Peng, T Zhang, Y Wu, X Wang, R Liu, X Jin - Colloids and Surfaces B …, 2023 - Elsevier
Non-invasive drug delivery offers a safe treatment while improving patient compliance.
However, due to the particular physiological structure of the ocular, long-term retention and …

3D printed ocusert laden with ultra-fluidic glycerosomes of ganciclovir for the management of ocular cytomegalovirus retinitis

MJ Naguib, YR Hassan, WH Abd-Elsalam - International Journal of …, 2021 - Elsevier
Cytomegalovirus (CMV) retinitis is a vision-threatening disease that principally afflicts
immunosuppressed patients. For the management of the disease, Ganciclovir (GCV) is …

Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED

A Garkal, P Bangar, A Rajput, P Pingale, N Dhas… - Journal of Controlled …, 2022 - Elsevier
The invigoration of protein and peptides in serious eye disease includes age-related
macular degeneration, choroidal neovascularization, retinal neovascularization, and …

The role of metalloproteinases and their tissue inhibitors on ocular diseases: focusing on potential mechanisms

M Caban, K Owczarek, U Lewandowska - International Journal of …, 2022 - mdpi.com
Eye diseases are associated with visual impairment, reduced quality of life, and may even
lead to vision loss. The efficacy of available treatment of eye diseases is not satisfactory. The …

Treatment Avenues for Age-Related Macular Degeneration: Breakthroughs and Bottlenecks

P Kumbhar, K Kolekar, S Vishwas, P Shetti… - Ageing Research …, 2024 - Elsevier
Age-related macular degeneration (AMD) is a significant factor contributing to serious vision
loss in adults above 50. The presence of posterior segment barriers serves as chief …