Single-cell methodologies and technologies have started a revolution in biology which until
recently has primarily been limited to deep sequencing and imaging modalities. With the …

We compared three cell isolation and two proteomic sample preparation methods for single-
cell and near-single-cell analysis. Whole blood was used to quantify hemoglobin (Hb) and …

Developments in quantitative proteomics and use of data-independent acquisition (DIA)
methodology is enabling measurement of proteins of interest in biological samples …

Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC)
have been hampered by a lack of biomarkers to identify early disease and therapeutic …

Abundant proteins challenge deep mass spectrometry (MS) analysis of the proteome. Yolk,
the source of food in many developing vertebrate embryos, complicates chemical separation …

There is increasing interest in developing in-depth proteomic approaches for mapping tissue
heterogeneity in a cell-type-specific manner to better understand and predict the function of …

We describe a sensitive and efficient workflow for label-free single-cell proteomics that
spans sample preparation, liquid chromatography separations, and mass spectrometry data …

Liquid chromatography-tandem mass spectrometry (LC–MS)-based profiling of proteomes
with isobaric tag labeling from low-quantity biological and clinical samples, including needle …

Profiling proteins plays an essential role in understanding the functions and dynamic
networks in biological systems. Mass spectrometry-based proteomic analysis commonly …

Background Efforts to address the poor prognosis associated with esophageal
adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early …