Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Glucocorticoids are widely used to suppress inflammation or the immune system. High
doses and long-term use of glucocorticoids lead to an important and common iatrogenic …

Regenerative medicine has sparked interest in potential strategies for bone repair. Bone
defects are widespread and could be caused by trauma, congenital malformations …

Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Osteocytes,> 90% of the cells in bone, lie embedded within the mineralized matrix and
coordinate osteoclast and osteoblast activity on bone surfaces by mechanisms still unclear …

Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …

Indian hedgehog (Ihh) is indispensable for development of the osteoblast lineage in the
endochondral skeleton. In order to determine whether Ihh is directly required for osteoblast …

Abstract Purpose of Review The mechanisms involved in the TNF-mediated deregulated
bone remodeling are little appreciated. This review will discuss and summarize the impact of …

Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration.
However, tracking cells and maintaining them in the site of injury is difficult. A potential …