Drug repositioning (also referred to as drug repurposing), the process of finding new uses of
existing drugs, has been gaining popularity in recent years. The availability of several …

The etiology of breast cancer might be explained by 2 mechanisms, namely, differentiation
and proliferation of breast epithelial cells mediated by hormonal factors. We performed a …

Identification of novel indications for commonly prescribed drugs could accelerate
translation of therapies. We investigated whether any clinically used drugs might be useful in …

Cardiac glycosides have a long history in the treatment of cardiac disease. However, several
preclinical studies as well as two phase I studies have shown that cardenolides may also …

Cardiac glycosides (CGs) are natural compounds sharing the ability to operate as potent
inhibitors of the plasma membrane Na+/K+-ATPase, hence promoting—via an indirect …

Research and development of new drugs requires both long time and high costs, whereas
safety and tolerability profiles make the success rate of approval very low. Drug repurposing …

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and
members of this class have been in clinical use for more than 1500 years. They have been …

Sodium potassium pump (Na+/K+ ATPase) is a transmembrane protein complex found in all
higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic …

Cardiac glycosides are plant-derived steroid-like compounds which have been used for the
treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+ …

Digitoxin is a cardiac glycoside currently being investigated for potential use in oncology;
however, an investigation of anticancer activity as a function of oligosaccharide chain length …