Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …

Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

The cytokine IFN-γ coordinates macrophage activation and is essential for control of
pathogens, including Mycobacterium tuberculosis. However, the mechanisms by which IFN …

Recent years have witnessed an emergence of interest in understanding metabolic changes
associated with immune responses, termed immunometabolism. As oxygen is central to all …

Understanding the physical characteristics of the local microenvironment in which
Mycobacterium tuberculosis resides is an important goal that may allow the targeting of …

Mycobacterium tuberculosis is a chronic, facultative intracellular pathogen that spends the
majority of its decades-long life cycle in a non-or slowly replicating state. However, the …

Background A significant body of evidence accumulated over the last century suggests a link
between hypoxic microenvironments within the infected host and the latent phase of …

The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among
HIV-infected individuals. We utilized the completed genome sequence and optimized …