Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …

Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …

Pro-and mature brain-derived neurotrophic factor (BDNF) activate two distinct receptors: p75
neurotrophin receptor (p75NTR) and TrkB. Mature BDNF facilitates hippocampal synaptic …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …

Neurotrophins are a unique family of polypeptide growth factors that influence the
proliferation, differentiation, survival and death of neuronal and non-neuronal cells. They are …

▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …

It is well documented that physical activity can induce a number of various stimuli which are
able to enhance the strength and endurance performance of muscles. Moreover, regular …

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family which interacts
with high-affinity protein kinase receptors (Trk) and the unselective p75NGFR receptor. The …