Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …

Cerebral malaria is the most severe neurological complication of infection with Plasmodium
falciparum. With> 575,000 cases annually, children in sub-Saharan Africa are the most …

Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but
platelets also have important immune functions. Platelets initiate and sustain vascular …

Background To prevent child deaths from severe malaria, early parenteral treatment is
essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials …

Nitric oxide (NO) is a gas that induces relaxation of smooth muscle cells in the vasculature.
Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by …

Malaria is a major public health problem in the developing world owing to its high rates of
morbidity and mortality. Of all the malarial parasites that infect humans, Plasmodium …

Central nervous system (CNS) infections are the main cause of seizures and acquired
epilepsy in the developing world. Geographical variations determine the common causes in …

Background Cerebral malaria (CM) is a neurological syndrome that includes coma and
seizures following malaria parasite infection. The pathophysiology is not fully understood …

The past decade has seen an unprecedented surge in political commitment and
international funding for malaria control. Coverage with existing control methods (ie, vector …

Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in
children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and …