Simple Summary The present review highlights and examines the importance of animal
models in relevant topics concerning current human and animal health. Over the past five …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but
their ability to recognize disease tissue and further achieve synergistic gene regulation has …

Inner ear gene therapy has recently effectively restored hearing in neonatal mice, but it is
complicated in adulthood by the structural inaccessibility of the cochlea, which is embedded …

Behavioural studies are of great importance in increasing our understanding and
appreciation of human and nonhuman animals. In addition to providing knowledge about …

Background Drug development is currently hampered by high attrition rates; many
developed treatments fail during clinical testing. Part of the attrition may be due to low …

Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …

Measuring Behaviour is the established go-to text for anyone interested in scientific methods
for studying the behaviour of animals or humans. It is widely used by students, teachers and …

Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …