Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021

Q Wu, W Qian, X Sun, S Jiang - Journal of hematology & oncology, 2022 - Springer
Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Frontiers in the treatment of glioblastoma: Past, present and emerging

TI Janjua, P Rewatkar, A Ahmed-Cox, I Saeed… - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Bifunctional cancer cell–based vaccine concomitantly drives direct tumor killing and antitumor immunity

KS Chen, C Reinshagen, TA Van Schaik… - Science Translational …, 2023 - science.org
The administration of inactivated tumor cells is known to induce a potent antitumor immune
response; however, the efficacy of such an approach is limited by its inability to kill tumor …

Ferritin–a multifaceted protein scaffold for biotherapeutics

NK Lee, S Cho, IS Kim - Experimental & Molecular Medicine, 2022 - nature.com
The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow
spherical structure that naturally stores iron ions has been diversely exploited by …

Cell‐based delivery systems: emerging carriers for immunotherapy

Z Li, Y Wang, Y Ding, L Repp… - Advanced Functional …, 2021 - Wiley Online Library
Immunotherapy is leading a paradigm shift in the treatment of various diseases, including
tumors, auto‐immune diseases, and infectious diseases. However, the limited response rate …

Cell surface engineering using DNAzymes: metal ion mediated control of cell–cell interactions

RC Qian, ZR Zhou, W Guo, Y Wu… - Journal of the American …, 2021 - ACS Publications
Regulating cell–cell interactions and cell behaviors via cell surface engineering is of
significance for biological research such as cell fate control and cell therapy. While …

Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules

Y Cao, E Ma, S Cestellos-Blanco… - Proceedings of the …, 2019 - National Acad Sciences
We present a simple nanopore-electroporation (NanoEP) platform for delivery of nucleic
acids, functional protein, and Cas9 single-guide RNA ribonucleoproteins into both adherent …

Applications of CRISPR as a potential therapeutic

R Luthra, S Kaur, K Bhandari - Life Sciences, 2021 - Elsevier
Genetic disorders and congenital abnormalities are present in 2-5% of births all over the
world and can cause up to 50% of all early childhood deaths. The establishment of …

Magnetic particle imaging: from Tracer Design to Biomedical Applications in vasculature abnormality

X Xie, J Zhai, X Zhou, Z Guo, PC Lo, G Zhu… - Advanced …, 2024 - Wiley Online Library
Magnetic particle imaging (MPI) is an emerging non‐invasive tomographic technique based
on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of …

Magnetically actuated cell‐robot system: precise control, manipulation, and multimode conversion

Y Dai, L Jia, L Wang, H Sun, Y Ji, C Wang, L Song… - Small, 2022 - Wiley Online Library
Border‐nearing microrobots with self‐propelling and navigating capabilities have promising
applications in micromanipulation and bioengineering, because they can stimulate the …