Matrix metalloproteinases, vascular remodeling, and vascular disease
X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
Angiotensin II and vascular injury
Vascular injury, characterized by endothelial dysfunction, structural remodelling,
inflammation and fibrosis, plays an important role in cardiovascular diseases. Cellular …
inflammation and fibrosis, plays an important role in cardiovascular diseases. Cellular …
Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease
MM Benjamin, RA Khalil - … Inhibitors: Specificity of Binding and Structure …, 2012 - Springer
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …
Angiotensin II and the vascular phenotype in hypertension
Hypertension is associated with vascular changes characterised by remodelling, endothelial
dysfunction and hyperreactivity. Cellular processes underlying these perturbations include …
dysfunction and hyperreactivity. Cellular processes underlying these perturbations include …
Matrix metalloproteinases and arterial hypertension: role of oxidative stress and nitric oxide in vascular functional and structural alterations
Various pathophysiological mechanisms have been implicated in hypertension, but those
resulting in vascular dysfunction and remodeling are critical and may help to identify critical …
resulting in vascular dysfunction and remodeling are critical and may help to identify critical …
Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension
VA Belo, DA Guimarães, MM Castro - Journal of vascular research, 2016 - karger.com
For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …
Matrix metaloproteinases in vascular pathology
Vascular diseases are the main cause of morbidity and mortality. The vascular extracellular
matrix (ECM) is essential in mechanical support, also regulating the cellular behavior …
matrix (ECM) is essential in mechanical support, also regulating the cellular behavior …
Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis
C Marchesi, F Dentali, E Nicolini… - Journal of …, 2012 - journals.lww.com
Background Hypertension is a major cause of cardiovascular remodeling. In the
cardiovascular system, the remodeling of the extracellular matrix is controlled by the matrix …
cardiovascular system, the remodeling of the extracellular matrix is controlled by the matrix …
Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases
MM Castro, AD Kandasamy, N Youssef… - Pharmacological …, 2011 - Elsevier
Matrix metalloproteinases (MMPs) are a family of proteases best known for their capacity to
proteolyse several proteins of the extracellular matrix. Their increased activity contributes to …
proteolyse several proteins of the extracellular matrix. Their increased activity contributes to …