A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …

Nowadays, nanotechnology-based modulation of the immune system is presented as a
cutting-edge strategy, which may lead to significant improvements in the treatment of severe …

Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells through a process
that is primarily mediated by T cells. Emerging evidence suggests that dendritic cells (DCs) …

We developed a novel poly (lactic-co-glycolic acid)-based, microparticle (MP) system
providing concurrent delivery of multiple encapsulated immuno-suppressive factors and …

The goal of immunotherapy against autoimmunity is to block pathogenic inflammation
without impairing immunity against infections and tumours. Regulatory T-cells (Tregs) play a …

The high prevalence and rising incidence of autoimmune diseases have become a
prominent public health issue. Autoimmune disorders result from the immune system …

Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …

Antigen specificity is a primary goal in developing curative therapies for autoimmune
disease. Dendritic cells (DCs), as the most effective antigen presenting cells in the body …

Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), play a key
role in initiating the body's immune response, maintain the balance of immunity. DCs can …

The prevalence of immune-mediated disorders, including autoimmune conditions and
allergies, is steadily increasing. However, current therapeutic approaches are often non …