The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …

The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

It has been 10 years since human metapneumovirus (HMPV) was identified as a causative
agent of respiratory illness in humans. Since then, numerous studies have contributed to a …

Human metapneumovirus (HMPV) is a leading cause of acute respiratory infection,
particularly in children, immunocompromised patients, and the elderly. HMPV, which is …

STAT1 belongs to the STAT family of transcription factors, which comprises seven factors:
STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT1 is a 91 kDa protein …

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …

Human metapneumovirus (HMPV) is an important cause of acute lower respiratory infection
in children and adults worldwide. There are four genetic subgroups of HMPV and both …

The interferon (IFN) system is integral to the host response against viruses, and many
viruses have developed strategies to overcome its antiviral effects. The effects of hepatitis E …

Type I interferons (IFN‐I) are a group of related proteins that help regulate the activity of the
immune system and play a key role in host defense against viral infections. Upon infection …