Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Adipose tissue (AT) is one of the largest endocrine organs contributing to metabolic
homeostasis. The functional pleiotropism of AT depends on its ability to secrete a large …

CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich
matricellular protein is emerging as a key player in the development and progression of …

Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

The diverse members of the CCN family now designated as CCN1 (CYR61), CCN2 (CTGF),
CCN3 (NOV), CCN4 (WISP1), CCN5 (WISP2), CCN6 (WISP3) are a conserved matricellular …

Severe obesity represents a major risk factor for the development of type 2 diabetes mellitus
(T2DM). Due to the strong association of obesity and diabetes, the term “diabesity” was …

Introduction: Dementia is the 7th leading cause of death that imposes a significant financial
and service burden on the global population. Presently, only symptomatic care exists for …

Context: Wnt1-inducible signaling pathway protein 1 (WISP1) is a novel adipokine
participating in adipose tissue (AT) dysfunction; so far, no data on WISP1 in diabetes are …

Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Background Wnt1-inducible signaling pathway protein 1, or cellular communication network
factor 4 (CCN4), a member of CCN family of secreted, extracellular matrix associated …