It is well accepted that ethanol is able to produce major health and economic problems
associated to its abuse. Because of its intoxicating and addictive properties, it is necessary …

Significant computational efforts have been focused toward exposing the molecular
mechanisms of anesthesia in recent years. In the past decade, this has been aided …

The pentameric ligand-gated ion channel (pLGIC) from Gloeobacter violaceus (GLIC) has
provided insightful structure–function views on the permeation process and the allosteric …

Ligand-gated ion channels are critical mediators of electrochemical signal transduction
across evolution. Biophysical and pharmacological characterization of these receptor …

Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous
system. These receptors have emerged as therapeutic targets in drug discovery for treating …

Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating
electrochemical signaling in neurons and other excitable cells. For many channels, the …

A new approach is presented for the application of single‐molecule imaging to membrane
receptors through the use of vesicles derived from cells expressing fluorescently labeled …

Pentameric ligand-gated ion-channels rapidly transduce synaptic neurotransmitter signals to
an electrical response in post-synaptic neuronal or muscle cells and control the …

The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands,
which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich …

Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of vertebrate pentameric
ligand-gated ion channels (pLGICs) and has proven to be a valuable model for …