RNA-based therapeutics: an overview and prospectus

Y Zhu, L Zhu, X Wang, H Jin - Cell death & disease, 2022 - nature.com
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …

Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Obstacles and opportunities in a forward vision for cancer nanomedicine

I de Lázaro, DJ Mooney - Nature materials, 2021 - nature.com
Cancer nanomedicines were initially envisioned as magic bullets, travelling through the
circulation to target tumours while sparing healthy tissues the toxicity of classic …

RNAi-based therapeutics and tumor targeted delivery in cancer

G Kara, GA Calin, B Ozpolat - Advanced drug delivery reviews, 2022 - Elsevier
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Recent progress of supramolecular chemotherapy based on host–guest interactions

M Yan, S Wu, Y Wang, M Liang, M Wang… - Advanced …, 2024 - Wiley Online Library
Chemotherapy is widely recognized as an effective approach for treating cancer due to its
ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional …

Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance

Y Yao, Y Zhou, L Liu, Y Xu, Q Chen, Y Wang… - Frontiers in molecular …, 2020 - frontiersin.org
Nanotechnology has been extensively studied and exploited for cancer treatment as
nanoparticles can play a significant role as a drug delivery system. Compared to …

Therapeutic siRNA: state of the art

B Hu, L Zhong, Y Weng, L Peng, Y Huang… - Signal transduction and …, 2020 - nature.com
ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …

Nucleic acid delivery for therapeutic applications

A Gupta, JL Andresen, RS Manan, R Langer - Advanced Drug Delivery …, 2021 - Elsevier
Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Recent advances in polymeric drug delivery systems

YK Sung, SW Kim - Biomaterials Research, 2020 - spj.science.org
Background Polymeric drug delivery systems have been achieved great development in the
last two decades. Polymeric drug delivery has defined as a formulation or a device that …

Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

FM Kashkooli, M Soltani, M Souri - Journal of controlled release, 2020 - Elsevier
Advances in nanomedicine, including early cancer detection, targeted drug delivery, and
personalized approaches to cancer treatment are on the rise. For example, targeted drug …