Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …

Abstract Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …

KRAS is the most frequently mutated oncogene in human cancer. In addition to holding this
distinction, unsuccessful attempts to target this protein have led to the characterization of …

Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …

Purpose The current study was designed to determine the risk of cancer in patients with
neurofibromatosis type 1 (NF1) by cancer type, age, and sex with unprecedented accuracy …

The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …

From the pioneering work with acute transforming retroviruses to the current post-genomic
era, RAS genes have always been at the leading edge of signal transduction and molecular …

Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

Ras genes are the most common targets for somatic gain-of-function mutations in human
cancer. Recently, germline mutations that affect components of the Ras–Raf–mitogen …