Grading the commercial optical biosensor literature—Class of 2008:'The Mighty Binders'

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2010 - Wiley Online Library
Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

Oleanolic acid derivatives for pharmaceutical use: A patent review

C Lin, X Wen, H Sun - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
Introduction: Oleanolic acid belongs to the pentacyclic triterpene family. In China, oleanolic
acid has been used as an over the counter (OTC) hepatoprotective drug for decades …

Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors

H Şenol, G Çelik Turgut, A Şen, R Sağlamtaş… - Medicinal Chemistry …, 2023 - Springer
In this study, a total of 13 compounds (5–17) were synthesized starting from oleanolic acid
(OA), a natural triterpenoid. Five new compounds (10, 11, 12, 15 and 17), are the main …

Harnessing oleanolic acid and its derivatives as modulators of metabolic nuclear receptors

MO Radwan, SF Kadasah, SM Aljubiri, AF Alrefaei… - Biomolecules, 2023 - mdpi.com
Nuclear receptors (NRs) constitute a superfamily of ligand-activated transcription factors with
a paramount role in ubiquitous physiological functions such as metabolism, growth, and …

Molecular mechanisms underlying the effects of olive oil triterpenic acids in obesity and related diseases

CM Claro-Cala, F Jiménez-Altayó, S Zagmutt… - Nutrients, 2022 - mdpi.com
Dietary components exert protective effects against obesity and related metabolic and
cardiovascular disturbances by interfering with the molecular pathways leading to these …

Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent

X Wang, YL Li, H Wu, JZ Liu, JX Hu… - Phytotherapy …, 2011 - Wiley Online Library
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia.
Although the clear mechanisms of DM and insulin resistance are still to be cleared, it has …

Overview of ursolic acid potential for the treatment of metabolic disorders, autoimmune diseases, and cancers via nuclear receptor pathways

SF Kadasah, MO Radwan - Biomedicines, 2023 - mdpi.com
Nuclear receptors (NRs) form a family of druggable transcription factors that are regulated by
ligand binding to orchestrate multifaceted physiological functions, including reproduction …

The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications

D Camer, Y Yu, A Szabo… - Molecular nutrition & food …, 2014 - Wiley Online Library
Recent research has uncovered the molecular mechanisms responsible for the therapeutic
properties of oleanolic acid (OA), its isomer ursolic acid (UA), and derivatives. In particular …

Small molecules from natural sources, targeting signaling pathways in diabetes

Q Liu, L Chen, L Hu, Y Guo, X Shen - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Diabetes mellitus (DM) is a metabolic disease caused by genetic or environmental factors. It
has rendered a severe menace to the middle-aged and elderly, while there is still lack of …

Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats

CT Musabayane, MA Tufts, RF Mapanga - Renal failure, 2010 - Taylor & Francis
Studies from our laboratories indicate that Syzygium cordatum leaf extract contains
triterpene mixtures [oleanolic acid (OA) and ursolic acid (UA)] with hypoglycemic properties …