Cystic fibrosis adult care: consensus conference report

JR Yankaskas, BC Marshall, B Sufian, RH Simon… - Chest, 2004 - journal.chestnet.org
Abbreviations: ADA Americans with Disabilities Act; BMD bone mineral density; BMI body
mass index; CBAVD congenital bilateral absence of the vas deferens; CF cystic fibrosis; CFF …

Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'

KN Lazaridis, GJ Gores, KD Lindor - Journal of hepatology, 2001 - journal-of-hepatology.eu
The use of ursodeoxycholic acid (UDCA) in the treatment of liver maladies originates in
ancient Chinese folk medicine. Indeed, for centuries, the Chinese drugyutan'a powder …

Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

CMP Rodrigues, X Ma, C Linehan-Stieers… - Cell Death & …, 1999 - nature.com
The hydrophilic bile salt ursodeoxycholic acid (UDCA) is a potent inhibitor of apoptosis. In
this paper, we further characterize the mechanism by which UDCA inhibits apoptosis …

High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis

DM Harnois, P Angulo, RA Jorgensen… - Official journal of the …, 2001 - journals.lww.com
OBJECTIVES: To assess the tolerability and efficacy of high-dose (25–30 mg/kg per day)
ursodeoxycholic acid (UDCA) in patients with primary sclerosing cholangitis (PSC) …

Epidemiology of liver disease in cystic fibrosis: a longitudinal study

T Lamireau, S Monnereau, S Martin, JE Marcotte… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: To describe the prevalence of liver disease in a cohort of 241 cystic
fibrosis (CF) patients. METHODS: 241 CF patients were followed-up every 3 months with …

[HTML][HTML] Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review

F Tonin, IWCE Arends - Beilstein journal of organic chemistry, 2018 - beilstein-journals.org
Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile
acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic …

[PDF][PDF] Ursodeoxycholic acid for liver disease associated with cystic fibrosis: A double‐blind multicenter trial

C Colombo, PM Battezzati, M Podda, N Bettinardi… - …, 1996 - Wiley Online Library
Liver disease is increasingly recognized as a major cause of morbidity in cystic fibrosis (CF).
Preliminary data suggest that ursodeoxycholic acid (UDCA) may be beneficial for treatment …

Analysis of risk factors for the development of liver disease associated with cystic fibrosis

C Colombo, MG Apostolo, M Ferrari, M Seia… - The Journal of …, 1994 - Elsevier
We prospectively screened for liver disease patients with cystic fibrosis who were more than
3 years of age and who were followed at the cystic fibrosis center of the University of Milan …

A two-year prospective study of the effect of ursodeoxycholic acid on urinary bile acid excretion and liver morphology in cystic fibrosis-associated liver disease

A Lindblad, H Glaumann, B Strandvik - Hepatology, 1998 - journals.lww.com
The efficacy of 2 years of treatment with ursodeoxycholic acid (UDCA) in cystic fibrosis (CF)-
associated liver disease was evaluated by liver biopsies and liver function tests in 10 …

Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy

D Brites, CMP Rodrigues, N Oliveira… - Journal of …, 1998 - Elsevier
Background/Aims: Intrahepatic cholestasis of pregnancy is characterized by pruritus and
increased levels of serum bile acids, and is often associated with premature delivery, fetal …