The mammalian forebrain-the cerebral cortex, basal ganglia, hypothalamus, and thalamus-
is the seat of higher cognitive functions. How much of forebrain develop-ment and structure …

Hox genes have a well-characterized role in embryonic development, where they determine
identity along the anteroposterior body axis. Hox genes are expressed not only during …

" A work of enormous breadth, likely to pleasantly surprise both general readers and
experts."—New York Times Book Review This revolutionary book provides fresh answers to …

Targeted gene disruption in the mouse shows that the Sonic hedgehog (Shh) gene plays a
critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord …

Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD),
profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT 2A …

Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system
modulates depression and anxiety-related behaviors in humans and rodents, but the …

ABSTRACT The genes Emx1 and Emx2 are mouse cognates of a Drosophila head gap
gene, empty spiracles, and their expression patterns have suggested their involvement in …

Homologies between vertebrate forebrain subdivisions are still uncertain. In particular the
identification of homologs of the mammalian neocortex or the dorsal ventricular ridge (DVR) …

Recent findings implicate embryonic signaling centers in patterning the mammalian cerebral
cortex. We used mouse in utero electroporation and mutant analysis to test whether cortical …

The organizing centers and molecules that pattern the cerebral cortex have been elusive.
Here we show that cortical patterning involves regulation of the Lhx2 homeobox gene by the …