The pathogenesis of obesity

SM Oussaada, KA Van Galen, MI Cooiman… - Metabolism, 2019 - Elsevier
Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Obesity: pathophysiology and intervention

Y Zhang, J Liu, J Yao, G Ji, L Qian, J Wang, G Zhang… - Nutrients, 2014 - mdpi.com
Obesity presents a major health hazard of the 21st century. It promotes co-morbid diseases
such as heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and …

Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of …

SJ Brooks, J Cedernaes, HB Schiöth - PloS one, 2013 - journals.plos.org
Background and Objectives Obesity is emerging as the most significant health concern of
the twenty-first century. A wealth of neuroimaging data suggest that weight gain might be …

Hungry brains: A meta-analytical review of brain activation imaging studies on food perception and appetite in obese individuals

F Devoto, L Zapparoli, R Bonandrini… - Neuroscience & …, 2018 - Elsevier
The dysregulation of food intake in chronic obesity has been explained by different theories.
To assess their explanatory power, we meta-analyzed 22 brain-activation imaging studies …

Reward processing in obesity, substance addiction and non‐substance addiction

I García‐García, A Horstmann, MA Jurado… - Obesity …, 2014 - Wiley Online Library
Similarities and differences between obesity and addiction are a prominent topic of ongoing
research. We conducted an activation likelihood estimation meta‐analysis on 87 studies in …

A core eating network and its modulations underlie diverse eating phenomena

J Chen, EK Papies, LW Barsalou - Brain and cognition, 2016 - Elsevier
We propose that a core eating network and its modulations account for much of what is
currently known about the neural activity underlying a wide range of eating phenomena in …

[HTML][HTML] Obesity affects brain structure and function-rescue by bariatric surgery?

MHC Nota, D Vreeken, M Wiesmann, EO Aarts… - Neuroscience & …, 2020 - Elsevier
Obesity has a major impact on metabolic health thereby negatively affecting brain function
and structure, however mechanisms involved are not entirely understood. The increasing …

Where is the comfort in comfort foods? Mechanisms linking fat signaling, reward, and emotion

N Weltens, D Zhao… - Neurogastroenterology & …, 2014 - Wiley Online Library
Background Food in general, and fatty foods in particular, have obtained intrinsic reward
value throughout evolution. This reward value results from an interaction between …

Food preferences and underlying mechanisms after bariatric surgery

P Behary, AD Miras - Proceedings of the Nutrition Society, 2015 - cambridge.org
Bariatric surgery leads to significant long-term weight loss, particularly Roux-en-Y gastric
bypass (RYGB). The mechanisms underlying weight loss have not been fully uncovered …

Obesity, body weight regulation and the brain: insights from fMRI

JM Makaronidis, RL Batterham - The British journal of radiology, 2018 - academic.oup.com
Obesity constitutes a major global health threat. Despite the success of bariatric surgery in
delivering sustainable weight loss and improvement in obesity-related morbidity, effective …