Clinical Trial Design for Lipoprotein(a)-Lowering Therapies: JACC Focus Seminar 2/3

WA Malick, SN Goonewardena, W Koenig… - Journal of the American …, 2023 - jacc.org
Abstract Lipoprotein (a)[Lp (a)] is a source of residual risk in patients with atherosclerotic
cardiovascular disease (ASCVD). Clinical trials of fully human monoclonal antibodies …

Addressing disparities in the global epidemiology of stroke

ML Prust, R Forman, B Ovbiagele - Nature Reviews Neurology, 2024 - nature.com
Stroke is the second leading cause of death and the third leading cause of disability
worldwide. Though the burden of stroke worldwide seems to have declined in the past three …

Development of an LC-MS/MS proposed candidate reference method for the standardization of analytical methods to measure lipoprotein (a)

SM Marcovina, N Clouet-Foraison… - Clinical …, 2021 - academic.oup.com
Background Use of lipoprotein (a) concentrations for identification of individuals at high risk
of cardiovascular diseases is hampered by the size polymorphism of apolipoprotein (a) …

Treatment and prevention of lipoprotein (a)-mediated cardiovascular disease: the emerging potential of RNA interference therapeutics

DI Swerdlow, DA Rider, A Yavari… - Cardiovascular …, 2022 - academic.oup.com
Lipid-and lipoprotein-modifying therapies have expanded substantially in the last 25 years,
resulting in reduction in the incidence of major adverse cardiovascular events. However, no …

Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis

P Kumar, P Swarnkar, S Misra, M Nath - Scientific reports, 2021 - nature.com
The role of lipoprotein-A [Lp (a)] as a risk factor for stroke is less well documented than for
coronary heart disease. Hence, we conducted a systematic review and meta-analysis for the …

Causal effect of Lp (a)[lipoprotein (a)] level on ischemic stroke and Alzheimer disease: a Mendelian randomization study

Y Pan, H Li, Y Wang, X Meng, Y Wang - Stroke, 2019 - Am Heart Assoc
Background and Purpose—Stroke and Alzheimer disease are 2 major causes of
neurological disability in aged people and shared overlapping predictors. In recent …

Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors

KL Ong, RL McClelland, MA Allison, M Cushman… - Metabolism, 2021 - Elsevier
Background Elevated plasma lipoprotein (a)[Lp (a)] and coronary artery calcification (CAC)
are established cardiovascular risk factors that correlate with each other. We hypothesized …

Association of red meat consumption, metabolic markers, and risk of cardiovascular diseases

L Pan, L Chen, J Lv, Y Pang, Y Guo, P Pei, H Du… - Frontiers in …, 2022 - frontiersin.org
Objective The metabolic mechanism of harmful effects of red meat on the cardiovascular
system is still unclear. The objective of the present study is to investigate the associations of …

Identifying genetic and biological determinants of race-ethnic disparities in stroke in the United States

D Kamin Mukaz, NA Zakai, S Cruz-Flores… - Stroke, 2020 - Am Heart Assoc
In the United States, causes of racial differences in stroke and its risk factors remain only
partly understood, and there is a long-standing disparity in stroke incidence and mortality …

Lipoprotein (a) and the risk for coronary heart disease and ischemic stroke events among black and white adults with cardiovascular disease

LD Colantonio, V Bittner, MM Safford… - Journal of the …, 2022 - Am Heart Assoc
Background It is unclear whether lipoprotein (a) is associated with coronary heart disease
(CHD) and ischemic stroke events in White and Black adults with atherosclerotic …