TGFβ/BMP signaling pathway in cartilage homeostasis

NGM Thielen, PM van der Kraan, APM van Caam - Cells, 2019 - mdpi.com
Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …

Role of TGF-β in skin chronic wounds: a keratinocyte perspective

S Liarte, Á Bernabé-García, FJ Nicolás - Cells, 2020 - mdpi.com
Chronic wounds are characterized for their incapacity to heal within an expected time frame.
Potential mechanisms driving this impairment are poorly understood and current hypotheses …

TGF-β signal transduction

J Massagué - Annual review of biochemistry, 1998 - annualreviews.org
The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …

Identification of extractable growth factors from small intestinal submucosa

SL Voytik‐Harbin, AO Brightman… - Journal of cellular …, 1997 - Wiley Online Library
When implanted as a biomaterial for tissue replacement, selected submucosal layers of
porcine small intestine induce site‐specific tissue remodeling. Small intestinal submucosa …

Transforming growth factor βs and wound healing

S O'Kane, MWJ Ferguson - The international journal of biochemistry & cell …, 1997 - Elsevier
The Transforming Growth Factor β superfamily (TGFβ) is one of the most complex groups of
cytokines with widespread effects on many aspects of growth and development. The TGFβ …

Specificity, diversity, and regulation in TGF‐β superfamily signaling

E Piek, CH HELDIN, PTEN DIJKE - The FASEB Journal, 1999 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) superfamily members are multifunctional cell‐cell
signaling proteins that play pivotal roles in tissue homeostasis and development of …

Physiological actions and clinical applications of transforming growth factor-β (TGF-β)

AB Roberts, MB Sporn - Growth factors, 1993 - Taylor & Francis
In the 10 years since its definition and characterization, TGF-β has come to be accepted as
the prototypical multifunctional peptide growth factor. Attempts to understand its mechanism …

TGF Beta− 1,− 2 and− 3 in the Modulation of Fibrosis in the Cornea and Other Organs

SE Wilson - Experimental eye research, 2021 - Elsevier
Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

Growth factors and antimicrobial factors of bovine colostrum

R Pakkanen, J Aalto - International Dairy Journal, 1997 - Elsevier
Colostrum is the first natural food produced by female mammals during the first 24–36h
directly after giving birth. Chemically, colostrum is a very complex fluid rich in nutrients …

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

J Taipale, K Miyazono, CH Heldin… - The Journal of cell …, 1994 - rupress.org
The role of latent transforming growth factor-beta (TGF-beta) binding protein (LTBP) in the
association of TGF-beta 1 to the extracellular matrix of cultured fibroblasts and HT-1080 …