Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction
Seizures are the most common neurological manifestation in the newborn period, with an
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …
KCNQ-encoded potassium channels as therapeutic targets
V Barrese, JB Stott, IA Greenwood - Annual review of …, 2018 - annualreviews.org
Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …
Driving with no brakes: molecular pathophysiology of Kv7 potassium channels
Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here,
we describe their molecular architecture, physiological roles, and involvement in genetically …
we describe their molecular architecture, physiological roles, and involvement in genetically …
The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients
Patients with ulcerative colitis (UC) using marijuana have been reported to experience
symptomatic benefit. Cannabidivarin (CBDV) is a safe non-psychoactive phytocannabinoid …
symptomatic benefit. Cannabidivarin (CBDV) is a safe non-psychoactive phytocannabinoid …
Effects of non‐euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice
FA Iannotti, E Pagano, AS Moriello… - British journal of …, 2019 - Wiley Online Library
Background and Purpose Duchenne muscular dystrophy (DMD), caused by dystrophin
deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration …
deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration …
Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus
Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are
activated at resting membrane potentials and therefore provide a powerful brake on …
activated at resting membrane potentials and therefore provide a powerful brake on …
The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels
Little is known of the involvement of endocannabinoids and cannabinoid receptors in
skeletal muscle cell differentiation. We report that, due to changes in the expression of …
skeletal muscle cell differentiation. We report that, due to changes in the expression of …
Novel treatment strategies for smooth muscle disorders: Targeting Kv7 potassium channels
JM Haick, KL Byron - Pharmacology & therapeutics, 2016 - Elsevier
Smooth muscle cells provide crucial contractile functions in visceral, vascular, and lung
tissues. The contractile state of smooth muscle is largely determined by their electrical …
tissues. The contractile state of smooth muscle is largely determined by their electrical …
[HTML][HTML] The dopamine system: insights between kidney and brain
A de Donato, V Buonincontri, G Borriello… - Kidney and Blood …, 2022 - karger.com
Background: Chronic kidney disease (CKD) is one of the most common diseases in adult
age, and it is typical of older adults. Recent data suggest that almost half of the elders have …
age, and it is typical of older adults. Recent data suggest that almost half of the elders have …