The synergy of scaffold-based and scaffold-free tissue engineering strategies

A Ovsianikov, A Khademhosseini, V Mironov - Trends in biotechnology, 2018 - cell.com
Tissue engineering (TE) is a highly interdisciplinary research field driven by the goal to
restore, replace, or regenerate defective tissues. Throughout more than two decades of …

The ECM: to scaffold, or not to scaffold, that is the question

JC Valdoz, BC Johnson, DJ Jacobs, NA Franks… - International Journal of …, 2021 - mdpi.com
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell
survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the …

Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs

N Di Caprio, JA Burdick - Acta biomaterialia, 2023 - Elsevier
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …

Biomimetic scaffolds for tissue engineering

TG Kim, H Shin, DW Lim - Advanced Functional Materials, 2012 - Wiley Online Library
Biomimetic scaffolds mimic important features of the extracellular matrix (ECM) architecture
and can be finely controlled at the nano‐or microscale for tissue engineering. Rational …

25th anniversary article: scalable multiscale patterned structures inspired by nature: the role of hierarchy

WG Bae, HN Kim, D Kim, SH Park… - Advanced …, 2014 - Wiley Online Library
Multiscale, hierarchically patterned surfaces, such as lotus leaves, butterfly wings, adhesion
pads of gecko lizards are abundantly found in nature, where microstructures are usually …

3D multispheroid assembly strategies towards tissue engineering and disease modeling

T Zhu, Y Hu, H Cui, H Cui - Advanced Healthcare Materials, 2024 - Wiley Online Library
Cell spheroids (esp. organoids) as 3D culture platforms are popular models for representing
cell–cell and cell–extracellular matrix (ECM) interactions, bridging the gap between 2D cell …

Combined additive manufacturing approaches in tissue engineering

SM Giannitelli, P Mozetic, M Trombetta, A Rainer - Acta biomaterialia, 2015 - Elsevier
Advances introduced by additive manufacturing (AM) have significantly improved the control
over the microarchitecture of scaffolds for tissue engineering. This has led to the flourishing …

Patterned prevascularised tissue constructs by assembly of polyelectrolyte hydrogel fibres

MF Leong, JKC Toh, C Du, K Narayanan, HF Lu… - Nature …, 2013 - nature.com
The in vivo efficacy of engineered tissue constructs depends largely on their integration with
the host vasculature. Prevascularisation has been noted to facilitate integration of the …

Scaffold-free, label-free and nozzle-free biofabrication technology using magnetic levitational assembly

VA Parfenov, EV Koudan, EA Bulanova… - …, 2018 - iopscience.iop.org
Tissue spheroids have been proposed as building blocks in 3D biofabrication. Conventional
magnetic force-driven 2D patterning of tissue spheroids requires prior cell labeling by …

[HTML][HTML] The utility of biomedical scaffolds laden with spheroids in various tissue engineering applications

SJ Chae, J Hong, H Hwangbo, GH Kim - Theranostics, 2021 - ncbi.nlm.nih.gov
A spheroid is a complex, spherical cellular aggregate supporting cell-cell and cell-matrix
interactions in an environment that mimics the real-world situation. In terms of tissue …