Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Contact inhibition enables noncancerous cells to cease proliferation and growth when they
contact each other. This characteristic is lost when cells undergo malignant transformation …

Macroautophagy, hereafter autophagy, is a degradative process conserved among
eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead …

Autophagy is a catabolic 'self-eating'pathway that is emerging as a crucial integration point
in cell physiology. With its own set of genes, the autophagy pathway communicates with …

Actin cytoskeleton dynamics play vital roles in most forms of intracellular trafficking by
promoting the biogenesis and transport of vesicular cargoes. Mounting evidence indicates …

Macroautophagy is an evolutionarily conserved dynamic pathway that functions primarily in
a degradative manner. A basal level of macroautophagy occurs constitutively, but this …